Difference between revisions of "BioW"
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=Expression and regulation= | =Expression and regulation= | ||
| − | + | * '''Operon:''' ''[[bioW]]-[[bioA]]-[[bioF]]-[[bioD]]-[[bioB]]-[[bioI]]-[[ytbQ]]'' {{PubMed|8763940,8892842}} | |
| − | * '''Operon:''' | ||
* '''[[Sigma factor]]:''' | * '''[[Sigma factor]]:''' | ||
* '''Regulation:''' | * '''Regulation:''' | ||
| + | ** repressed in the presence of biotin ([[BirA]]) {{PubMed|8763940,8892842}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| + | ** [[BirA]]: transcription repression {{PubMed|8763940,8892842}} | ||
| − | * '''Additional information:''' | + | * '''Additional information:''' |
=Biological materials = | =Biological materials = | ||
Revision as of 19:38, 19 December 2009
- Description: 6-carboxyhexanoate-CoA ligase
| Gene name | bioW |
| Synonyms | |
| Essential | no |
| Product | 6-carboxyhexanoate-CoA ligase) |
| Function | biosynthesis of biotin |
| MW, pI | 29 kDa, 5.548 |
| Gene length, protein length | 777 bp, 259 aa |
| Immediate neighbours | bioA, ytaP |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU30240
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate + 6-carboxyhexanoyl-CoA (according to Swiss-Prot)
- Protein family: bioW family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: P53559
- KEGG entry: [3]
- E.C. number: 6.2.1.14
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
