Difference between revisions of "ArsC"
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=Expression and regulation= | =Expression and regulation= | ||
| + | * '''Operon:''' ''[[arsR]]-[[yqcK]]-[[arsB]]-[[arsC]]'' {{PubMed|9537360}} | ||
| − | * | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|9537360}}, [[SigF]] {{PubMed|16497325}} |
| − | |||
| − | |||
* '''Regulation:''' | * '''Regulation:''' | ||
** expressed early during sporulation in the forespore ([[SigF]]) {{PubMed|16497325}} | ** expressed early during sporulation in the forespore ([[SigF]]) {{PubMed|16497325}} | ||
| − | ** | + | ** expressed in the presence of toxic metal ions (As(III), Cd(II) and Ag(I)) ([[ArsR]]) {{PubMed|9537360}} |
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| − | ** [[ArsR]]: transcription repression | + | ** [[ArsR]]: transcription repression {{PubMed|9537360}} |
* '''Additional information:''' | * '''Additional information:''' | ||
Revision as of 20:07, 24 November 2009
- Description: arsenate reductase
| Gene name | arsC |
| Synonyms | yqcM |
| Essential | no |
| Product | arsenate reductase |
| Function | detoxification of arsenate |
| MW, pI | 15 kDa, 4.749 |
| Gene length, protein length | 417 bp, 139 aa |
| Immediate neighbours | spoIVCA, arsB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU25780
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate (according to Swiss-Prot)
- Protein family: ArsC family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
Database entries
- UniProt: P45947
- KEGG entry: [3]
- E.C. number: 3.1.3.48
Additional information
Expression and regulation
- Regulation:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Stephanie T Wang, Barbara Setlow, Erin M Conlon, Jessica L Lyon, Daisuke Imamura, Tsutomu Sato, Peter Setlow, Richard Losick, Patrick Eichenberger
The forespore line of gene expression in Bacillus subtilis.
J Mol Biol: 2006, 358(1);16-37
[PubMed:16497325]
[WorldCat.org]
[DOI]
(P p)
Z Guan, L Hederstedt, J Li, X D Su
Preparation and crystallization of a Bacillus subtilis arsenate reductase.
Acta Crystallogr D Biol Crystallogr: 2001, 57(Pt 11);1718-21
[PubMed:11679756]
[WorldCat.org]
[DOI]
(P p)
T Sato, Y Kobayashi
The ars operon in the skin element of Bacillus subtilis confers resistance to arsenate and arsenite.
J Bacteriol: 1998, 180(7);1655-61
[PubMed:9537360]
[WorldCat.org]
[DOI]
(P p)
