Difference between revisions of "DprA"
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| − | * '''Description:''' conveys incoming ssDNA to RecA <br/><br/> | + | * '''Description:''' conveys incoming ssDNA to [[RecA]] <br/><br/> |
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* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU16110] | * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU16110] | ||
| − | |||
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=== Additional information=== | === Additional information=== | ||
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=Expression and regulation= | =Expression and regulation= | ||
| − | * '''Operon:''' | + | * '''Operon:''' ''dprA'' (according to [http://dbtbs.hgc.jp/COG/prom/smf.html DBTBS]) |
* '''[[Sigma factor]]:''' | * '''[[Sigma factor]]:''' | ||
* '''Regulation:''' | * '''Regulation:''' | ||
| + | ** expressed under conditions that trigger genetic competence ([[ComK]]) {{PubMed|11948146}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| + | ** [[ComK]]: transcription activation {{PubMed|11948146}} | ||
* '''Additional information:''' | * '''Additional information:''' | ||
| Line 120: | Line 120: | ||
=References= | =References= | ||
| − | <pubmed>17630974,17803906,12421306,18045469 , </pubmed> | + | <pubmed>17630974,17803906,12421306,18045469 11948146 , </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 16:28, 11 October 2009
- Description: conveys incoming ssDNA to RecA
| Gene name | dprA |
| Synonyms | smf |
| Essential | no |
| Product | recombination mediator protein |
| Function | genetic transformation |
| MW, pI | 32 kDa, 9.755 |
| Gene length, protein length | 891 bp, 297 aa |
| Immediate neighbours | sucD, topA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU16110
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: smf family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
Database entries
- Structure:
- UniProt: P39813
- KEGG entry: [3]
Additional information
Expression and regulation
- Operon: dprA (according to DBTBS)
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Peter Graumann, Freiburg University, Germany homepage
Your additional remarks
References
Serkalem Tadesse, Peter L Graumann
DprA/Smf protein localizes at the DNA uptake machinery in competent Bacillus subtilis cells.
BMC Microbiol: 2007, 7;105
[PubMed:18045469]
[WorldCat.org]
[DOI]
(I e)
Isabelle Mortier-Barrière, Marion Velten, Pauline Dupaigne, Nicolas Mirouze, Olivier Piétrement, Stephen McGovern, Gwennaele Fichant, Bernard Martin, Philippe Noirot, Eric Le Cam, Patrice Polard, Jean-Pierre Claverys
A key presynaptic role in transformation for a widespread bacterial protein: DprA conveys incoming ssDNA to RecA.
Cell: 2007, 130(5);824-36
[PubMed:17803906]
[WorldCat.org]
[DOI]
(P p)
Naomi Kramer, Jeanette Hahn, David Dubnau
Multiple interactions among the competence proteins of Bacillus subtilis.
Mol Microbiol: 2007, 65(2);454-64
[PubMed:17630974]
[WorldCat.org]
[DOI]
(P p)
Janet C Lindow, Masayoshi Kuwano, Shigeki Moriya, Alan D Grossman
Subcellular localization of the Bacillus subtilis structural maintenance of chromosomes (SMC) protein.
Mol Microbiol: 2002, 46(4);997-1009
[PubMed:12421306]
[WorldCat.org]
[DOI]
(P p)
Mitsuo Ogura, Hirotake Yamaguchi, Kazuo Kobayashi, Naotake Ogasawara, Yasutaro Fujita, Teruo Tanaka
Whole-genome analysis of genes regulated by the Bacillus subtilis competence transcription factor ComK.
J Bacteriol: 2002, 184(9);2344-51
[PubMed:11948146]
[WorldCat.org]
[DOI]
(P p)
