FolE2

• Description: type I GTP cyclohydrolase involved in zinc transport
  
  

Gene name	yciA
Synonyms
Essential	no
Product	type I GTP cyclohydrolase
Function	zinc uptake
MW, pI	34 kDa, 7.831
Gene length, protein length	915 bp, 305 aa
Immediate neighbours	nasA, yciB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU03340

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: GTP + H₂O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate (according to Swiss-Prot)

• Protein family: GTP cyclohydrolase IV family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P94398

• KEGG entry: [3]

• E.C. number: 3.5.4.16

Expression and regulation

• Operon:

• [[Sigma factor]]:

• Regulation:
  • induced by zinc starvation (Zur) PubMed

• Regulatory mechanism:
  • Zur: transcription repression in the presence of zinc PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: