Difference between revisions of "XylA"
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Revision as of 10:58, 21 July 2009
- Description: xylose isomerase
Gene name | xylA |
Synonyms | |
Essential | no |
Product | xylose isomerase |
Function | utilization of xylan and xylose |
Metabolic function and regulation of this protein in SubtiPathways: Sugar catabolism | |
MW, pI | 50 kDa, 5.635 |
Gene length, protein length | 1335 bp, 445 aa |
Immediate neighbours | xylR, xylB |
Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context This image was kindly provided by SubtiList
|
Contents
The gene
Basic information
- Locus tag: BSU17600
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: D-xylose = D-xylulose (according to Swiss-Prot)
- Protein family: xylose isomerase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure: 1A0D (Geobacillus stearothermophilus)
- UniProt: P04788
- KEGG entry: [3]
- E.C. number: 5.3.1.5
Additional information
Expression and regulation
- Regulation: repressed by glucose (CcpA) , carbon catabolite repression (CcpA), induction by xylose (XylR)
- Regulatory mechanism: CcpA: transcription repression, CcpA: transcription repression, XylR: transcription repression
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Wolfgang Hillen, Erlangen University, Germany Homepage
Your additional remarks
References
M K Dahl, J Degenkolb, W Hillen
Transcription of the xyl operon is controlled in Bacillus subtilis by tandem overlapping operators spaced by four base-pairs.
J Mol Biol: 1994, 243(3);413-24
[PubMed:7966270]
[WorldCat.org]
[DOI]
(P p)
A Kraus, C Hueck, D Gärtner, W Hillen
Catabolite repression of the Bacillus subtilis xyl operon involves a cis element functional in the context of an unrelated sequence, and glucose exerts additional xylR-dependent repression.
J Bacteriol: 1994, 176(6);1738-45
[PubMed:8132469]
[WorldCat.org]
[DOI]
(P p)
D Gärtner, J Degenkolb, J A Ripperger, R Allmansberger, W Hillen
Regulation of the Bacillus subtilis W23 xylose utilization operon: interaction of the Xyl repressor with the xyl operator and the inducer xylose.
Mol Gen Genet: 1992, 232(3);415-22
[PubMed:1588910]
[WorldCat.org]
[DOI]
(P p)
S Jacob, R Allmansberger, D Gärtner, W Hillen
Catabolite repression of the operon for xylose utilization from Bacillus subtilis W23 is mediated at the level of transcription and depends on a cis site in the xylA reading frame.
Mol Gen Genet: 1991, 229(2);189-96
[PubMed:1921970]
[WorldCat.org]
[DOI]
(P p)
D Gärtner, M Geissendörfer, W Hillen
Expression of the Bacillus subtilis xyl operon is repressed at the level of transcription and is induced by xylose.
J Bacteriol: 1988, 170(7);3102-9
[PubMed:2454911]
[WorldCat.org]
[DOI]
(P p)