Difference between revisions of "Btr"
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| − | * '''Description:''' transcription activator ( | + | * '''Description:''' transcription activator (AraC family DNA-binding domain fused to [[FeuA]]-like substrate-binding domain), regulation of the ''[[feuA]]-[[feuB]]-[[feuC]]-[[ybbA]]'' operon <br/><br/> |
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=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' | + | * '''Catalyzed reaction/ biological activity:''' transcription activation of the ''[[feuA]]-[[feuB]]-[[feuC]]-[[ybbA]]'' operon in the presence of bacillibactin or enterobactin [http://www.ncbi.nlm.nih.gov/sites/entrez/17725565 PubMed] |
* '''Protein family:''' | * '''Protein family:''' | ||
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* '''Modification:''' | * '''Modification:''' | ||
| − | * '''Cofactor(s):''' | + | * '''Cofactor(s):''' enterobactin, bacillibactin (co-activators) [http://www.ncbi.nlm.nih.gov/sites/entrez/17725565 PubMed] |
| − | * '''Effectors of protein activity:''' | + | * '''Effectors of protein activity:''' enterobactin, bacillibactin (co-activators) [http://www.ncbi.nlm.nih.gov/sites/entrez/17725565 PubMed] |
* '''Interactions:''' | * '''Interactions:''' | ||
| Line 95: | Line 95: | ||
* '''Regulation:''' | * '''Regulation:''' | ||
| − | ** | + | ** expressed under conditions of iron starvation ([[Fur]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed] |
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
Revision as of 20:41, 27 June 2009
- Description: transcription activator (AraC family DNA-binding domain fused to FeuA-like substrate-binding domain), regulation of the feuA-feuB-feuC-ybbA operon
| Gene name | btr |
| Synonyms | ybbB, yzbC |
| Essential | no |
| Product | transcription activator (AraC family) |
| Function | regulation of iron acquisition |
| Metabolic function and regulation of this protein in SubtiPathways: Stress | |
| MW, pI | 60 kDa, 6.433 |
| Gene length, protein length | 1587 bp, 529 aa |
| Immediate neighbours | feuA, ybbC |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU01640
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: transcription activation of the feuA-feuB-feuC-ybbA operon in the presence of bacillibactin or enterobactin PubMed
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s): enterobactin, bacillibactin (co-activators) PubMed
- Effectors of protein activity: enterobactin, bacillibactin (co-activators) PubMed
- Interactions:
- Localization:
Database entries
- Structure:
- Swiss prot entry: P40408
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Additional information: the mRNA is very stable (half-life > 15 min) PubMed
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Ahmed Gaballa, John D Helmann
Substrate induction of siderophore transport in Bacillus subtilis mediated by a novel one-component regulator.
Mol Microbiol: 2007, 66(1);164-73
[PubMed:17725565]
[WorldCat.org]
[DOI]
(P p)
G Hambraeus, C von Wachenfeldt, L Hederstedt
Genome-wide survey of mRNA half-lives in Bacillus subtilis identifies extremely stable mRNAs.
Mol Genet Genomics: 2003, 269(5);706-14
[PubMed:12884008]
[WorldCat.org]
[DOI]
(P p)
Noel Baichoo, Tao Wang, Rick Ye, John D Helmann
Global analysis of the Bacillus subtilis Fur regulon and the iron starvation stimulon.
Mol Microbiol: 2002, 45(6);1613-29
[PubMed:12354229]
[WorldCat.org]
[DOI]
(P p)
