Difference between revisions of "HemA"

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* '''Swiss prot entry:''' [http://www.uniprot.org/uniprot/P16618 P16618]
 
* '''Swiss prot entry:''' [http://www.uniprot.org/uniprot/P16618 P16618]
  
* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu+BSU28170]
+
* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU28170]
  
 
* '''E.C. number:''' [http://www.expasy.org/enzyme/1.2.1.70 1.2.1.70]
 
* '''E.C. number:''' [http://www.expasy.org/enzyme/1.2.1.70 1.2.1.70]

Revision as of 02:37, 25 June 2009

  • Description: glutamyl-tRNA reductase

Gene name hemA
Synonyms
Essential no
Product glutamyl-tRNA reductase
Function porphyrin biosynthesis
MW, pI 50 kDa, 5.313
Gene length, protein length 1365 bp, 455 aa
Immediate neighbours yhfU, yhfW
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
HemA context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU28170

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: L-glutamate 1-semialdehyde + NADP+ + tRNA(Glu) = L-glutamyl-tRNA(Glu) + NADPH (according to Swiss-Prot)
  • Protein family: glutamyl-tRNA reductase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cell membrane (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
    • repressed in the absence of hydrogen peroxide (PerR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References