Spx - Revision history

Jstuelk: /* Original Publications */

2014-12-05T18:16:51Z

‎Original Publications

Show changes

Jstuelk: /* Expression and regulation */

2014-10-31T12:29:51Z

‎Expression and regulation

Jstuelk: /* Original Publications */

2014-10-31T12:25:10Z

‎Original Publications

Jstuelk at 10:51, 20 June 2014

2014-06-20T10:51:32Z

134.76.70.252 at 10:10, 17 April 2014

2014-04-17T10:10:15Z

134.76.38.147 at 13:25, 2 April 2014

2014-04-02T13:25:06Z

Jstuelk at 09:28, 16 January 2014

2014-01-16T09:28:50Z

134.76.70.252 at 10:31, 7 January 2014

2014-01-07T10:31:17Z

134.76.70.252 at 14:15, 18 November 2013

2013-11-18T14:15:28Z

Jstuelk at 19:21, 15 September 2013

2013-09-15T19:21:06Z

@@ Line 144: / Line 144: @@
 ** post-translational control by [[ClpX]]-[[ClpP]]: Spx naturally contains a C-terminal sequence that resembles the [[SsrA]] tag and targets the protein for degradation. [http://www.ncbi.nlm.nih.gov/pubmed/12642660?ordinalpos=27&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum PubMed]
 ** proteolysis is enhanced by [[YjbH]] [http://www.ncbi.nlm.nih.gov/pubmed/19074380?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum PubMed] and counter-acted by [[YirB]] {{PubMed|21378193}}
 ** the mRNA is substantially stabilized upon depletion of [[Rny|RNase Y]] (the half-life of the monocistronic ''spx'' mRNA increases from 1 to 6 min) {{PubMed|21815947}}
 ** number of protein molecules per cell (complex medium with amino acids, without glucose): 83 {{PubMed|24696501}}

@@ Line 180: / Line 180: @@
 <pubmed> 19580872, 16249335, 23813734 </pubmed>
 ==Original Publications==
-<pubmed>21378193,22307755 18487332,17908206,17434969,17158660, 19074380, 15805528, 18662407, 16885442, 18179421, 17434969, 17908206, 17158660, 11703662, 15659166, 12642660, 12057962, 10482513, 18687074, 12775685, 16740936, 17827297, 20084284 20057163 10913081 21815947 23894131 23934352 22582280 24417481 24942655 </pubmed>
+<pubmed>21378193,22307755 18487332,17908206,17434969,17158660, 19074380, 15805528, 18662407, 16885442, 18179421, 17434969, 17908206, 17158660, 11703662, 15659166, 12642660, 12057962, 10482513, 18687074, 12775685, 16740936, 17827297, 20084284 20057163 10913081 21815947 23894131 23934352 22582280 24417481 24942655 25353645 </pubmed>
 [[Category:Protein-coding genes]]

@@ Line 38: / Line 38: @@
 <br/><br/><br/><br/>
 <br/><br/><br/><br/>
@@ Line 181: / Line 180: @@
 <pubmed> 19580872, 16249335, 23813734 </pubmed>
 ==Original Publications==
-<pubmed>21378193,22307755 18487332,17908206,17434969,17158660, 19074380, 15805528, 18662407, 16885442, 18179421, 17434969, 17908206, 17158660, 11703662, 15659166, 12642660, 12057962, 10482513, 18687074, 12775685, 16740936, 17827297, 20084284 20057163 10913081 21815947 23894131 23934352 22582280 24417481 </pubmed>
+<pubmed>21378193,22307755 18487332,17908206,17434969,17158660, 19074380, 15805528, 18662407, 16885442, 18179421, 17434969, 17908206, 17158660, 11703662, 15659166, 12642660, 12057962, 10482513, 18687074, 12775685, 16740936, 17827297, 20084284 20057163 10913081 21815947 23894131 23934352 22582280 24417481 24942655 </pubmed>
 [[Category:Protein-coding genes]]

@@ Line 146: / Line 146: @@
 ** proteolysis is enhanced by [[YjbH]] [http://www.ncbi.nlm.nih.gov/pubmed/19074380?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum PubMed] and counter-acted by [[YirB]] {{PubMed|21378193}}
 ** the mRNA is substantially stabilized upon depletion of [[Rny|RNase Y]] (the half-life of the monocistronic ''spx'' mRNA increases from 1 to 6 min) {{PubMed|21815947}}
 =Biological materials =

@@ Line 66: / Line 66: @@
 === Database entries ===
 * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/yjbCD.html]
@@ Line 107: / Line 108: @@
 === Database entries ===
 * '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=1Z3E 1Z3E] complex with C-terminal domain of [[RpoA]] [http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?Dopt=s&uid=35536 NCBI]

@@ Line 1: / Line 1: @@
-* '''Description:''' transcriptional regulator Spx, involved in regulation of many genes, required for protection against paraquat stress  <br/><br/>
+* '''Description:''' transcriptional regulator Spx, involved in regulation of many genes, important for the prevention of protein aggregation during severe heat stress, required for protection against paraquat stress  <br/><br/>
 {| align="right" border="1" cellpadding="2"
 |-
@@ Line 91: / Line 91: @@
 * '''Kinetic information:'''
-* '''Domains:''' CXXC (10-13): Acts as a disulfide switch for the redox-sensitive transcriptional regulation of genes that function in thiol homeostasis.
+* '''[[Domains]]:''' CXXC (10-13): Acts as a disulfide switch for the redox-sensitive transcriptional regulation of genes that function in thiol homeostasis.
 * '''Modification:''' Cysteine oxidation of the CXXC motif
-* '''Cofactor(s):'''
+* '''[[Cofactors]]:'''
 * '''Effectors of protein activity:'''
@@ Line 178: / Line 178: @@
 <pubmed> 19580872, 16249335, 23813734 </pubmed>
 ==Original Publications==
-<pubmed>21378193,22307755 18487332,17908206,17434969,17158660, 19074380, 15805528, 18662407, 16885442, 18179421, 17434969, 17908206, 17158660, 11703662, 15659166, 12642660, 12057962, 10482513, 18687074, 12775685, 16740936, 17827297, 20084284 20057163 10913081 21815947 23894131 23934352 22582280</pubmed>
+<pubmed>21378193,22307755 18487332,17908206,17434969,17158660, 19074380, 15805528, 18662407, 16885442, 18179421, 17434969, 17908206, 17158660, 11703662, 15659166, 12642660, 12057962, 10482513, 18687074, 12775685, 16740936, 17827297, 20084284 20057163 10913081 21815947 23894131 23934352 22582280 24417481 </pubmed>
 [[Category:Protein-coding genes]]

@@ Line 17: / Line 17: @@
 |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=Spx Spx]
 |-
-|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/riboflavin.html Riboflavin / FAD]'''
+|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=spx spx]'''
 |-
 |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 15,5 kDa, 7.80

@@ Line 15: / Line 15: @@
 |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU11500 spx]
 |-
-|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/Spx Spx]
+|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=Spx Spx]
 |-
 |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/riboflavin.html Riboflavin / FAD]'''

@@ Line 1: / Line 1: @@
-* '''Description:''' transcriptional regulator Spx, involved in regulation of many genes. <br/><br/>
+* '''Description:''' transcriptional regulator Spx, involved in regulation of many genes, required for protection against paraquat stress  <br/><br/>
 {| align="right" border="1" cellpadding="2"
 |-
@@ Line 44: / Line 44: @@
 {{SubtiWiki category|[[transcription factors and their control]]}},
 {{SubtiWiki category|[[general stress proteins (controlled by SigB)]]}},
-{{SubtiWiki category|[[cell envelope stress proteins (controlled by SigM, V, W, X, Y)]]}}
+{{SubtiWiki category|[[cell envelope stress proteins (controlled by SigM, V, W, X, Y)]]}},
 = This gene is a member of the following [[regulons]] =
@@ Line 177: / Line 178: @@
 <pubmed> 19580872, 16249335, 23813734 </pubmed>
 ==Original Publications==
-<pubmed>21378193,22307755 18487332,17908206,17434969,17158660, 19074380, 15805528, 18662407, 16885442, 18179421, 17434969, 17908206, 17158660, 11703662, 15659166, 12642660, 12057962, 10482513, 18687074, 12775685, 16740936, 17827297, 20084284 20057163 10913081 21815947 23894131 23934352</pubmed>
+<pubmed>21378193,22307755 18487332,17908206,17434969,17158660, 19074380, 15805528, 18662407, 16885442, 18179421, 17434969, 17908206, 17158660, 11703662, 15659166, 12642660, 12057962, 10482513, 18687074, 12775685, 16740936, 17827297, 20084284 20057163 10913081 21815947 23894131 23934352 22582280</pubmed>
 [[Category:Protein-coding genes]]