KinA - Revision history

Jstuelk: /* Original Publications */

2015-07-15T09:29:38Z

‎Original Publications

Jstuelk: /* Original Publications */

2015-06-10T08:58:40Z

‎Original Publications

Jstuelk: /* Original Publications */

2015-01-20T09:39:37Z

‎Original Publications

Jstuelk: /* Extended information on the protein */

2014-10-27T16:14:28Z

‎Extended information on the protein

134.76.38.147 at 13:34, 2 April 2014

2014-04-02T13:34:29Z

134.76.70.252 at 10:39, 7 January 2014

2014-01-07T10:39:14Z

134.76.70.252 at 16:08, 11 November 2013

2013-11-11T16:08:08Z

134.76.70.252 at 13:08, 16 May 2013

2013-05-16T13:08:30Z

134.76.70.252 at 10:04, 14 May 2013

2013-05-14T10:04:22Z

134.76.70.252 at 12:41, 13 May 2013

2013-05-13T12:41:36Z

← Older revision		Revision as of 09:29, 15 July 2015
Line 1:		Line 1:
−	* '''Description:~~''' [[two-component systems\|two-component]] sensor kinase, phosphorylates [[Spo0F]], part of the [[phosphorelay]] <br/><br/>~~	+	{{#bank: KinA}}

−	~~{\| align="right" border="1" cellpadding="2"~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\|'''Gene name'''~~
−	~~\|''kinA''~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Synonyms''' \|\| ''spoIIF, spoIIJ, gsiC, scoB, scoD ''~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Essential''' \|\| no~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Product''' \|\| [[two-component systems\|two-component]] sensor kinase~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\|'''Function''' \|\| initiation of sporulation~~
−	\|-
−	\|colspan="2" style="background:#FAF8CC;" align="center"\| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU13990 kinA]
−	\|-
−	\|colspan="2" style="background:#FAF8CC;" align="center"\| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=KinA KinA]
−	\|-
−	\|colspan="2" style="background:#FAF8CC;" align="center"\| '''Function and regulation of this protein in [[SubtiPathways\|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=kinA kinA]'''
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''MW, pI''' \|\| 68 kDa, 5.491~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Gene length, protein length''' \|\| 1818 bp, 606 aa~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\|'''Immediate neighbours''' \|\| ''[[pbpH]]'', ''[[patA]]''~~
−	\|-
−	\|style="background:#FAF8CC;" align="center"\|'''Sequences'''\|\|[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU13990 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU13990 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU13990 DNA_with_flanks]
−	\|-
−	~~\|colspan="2" \| '''Genetic context''' <br/> [[Image:kinA_context.gif]]~~
−	~~<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>~~
−	\|-
−	\|colspan="2" \|'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=kinA_1470026_1471846_1 Expression at a glance]'''   {{PubMed\|22383849}}<br/>[[Image:kinA_expression.png\|500px\|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU13990]]
−	\|-
−	\|}
−
−	~~__TOC__~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/>~~
−
−	~~= [[Categories]] containing this gene/protein =~~
−	~~{{SubtiWiki category\|[[protein modification]]}},~~
−	~~{{SubtiWiki category\|[[transcription factors and their control]]}},~~
−	~~{{SubtiWiki category\|[[phosphorelay]]}},~~
−	~~{{SubtiWiki category\|[[phosphoproteins]]}}~~
−
−	~~= This gene is a member of the following [[regulons]] =~~
−	~~{{SubtiWiki regulon\|[[SigH regulon]]}},~~
−	~~{{SubtiWiki regulon\|[[Spo0A regulon]]}},~~
−	~~{{SubtiWiki regulon\|[[stringent response]]}}~~
−
−	~~=The gene=~~
−
−	~~=== Basic information ===~~
−
−	* '''Locus tag:''' BSU13990
−
−	~~===Phenotypes of a mutant ===~~
−
−	~~=== Database entries ===~~
−	* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU13990&redirect=T BSU13990]
−
−	* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/kinA.html]
−
−	* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10204]
−
−	~~=== Additional information===~~
−
−
−
−
−	~~=The protein=~~
−
−	~~=== Basic information/ Evolution ===~~
−
−	* '''Catalyzed reaction/ biological activity:'''
−	** autophosphorylation, phosphorylation of [[Spo0F]]
−	** mainly active in the older, inner regions of a colony (with [[KinB]]) {{PubMed\|21097618}}
−
−	* '''Protein family:'''
−
−	* '''Paralogous protein(s):'''
−
−	~~=== Extended information on the protein ===~~
−
−	* '''Kinetic information:'''
−
−	* '''Domains:'''
−	** three tandem [[PAS domain]]s in the N-terminal region of KinA, the [[second PAS]] domain is the major N-terminal determinant of KinA dimerization {{PubMed\|23504013}}
−	** the first [[PAS domain]] is required for NAD(+) binding {{PubMed\|23599347}}
−	** C-terminal histidine phosphotransferase domain
−
−	* '''Modification:''' autophosphorylation on a His residue
−
−	* '''Cofactor(s):'''
−
−	* '''Effectors of protein activity:'''
−	** interaction with [[KipI]] or [[Sda]] inhibits autophosphorylation of [[KinA]] {{PubMed\|9334321,15023339}}
−	** autophosphorylation is inhibited by [[SivA]] and [[BslA]] {{PubMed\|23335417}}
−	** activated by interaction with NAD(+) that indicated poor respiratory activity of the cell {{PubMed\|23599347}}
−
−	* '''[[SubtInteract\|Interactions]]:'''
−	** forms tetramers {{PubMed\|21926229}}
−	** [[KinA]]-[[KipI]] {{PubMed\|9334321}}
−	** [[KinA]]-[[Sda]] {{PubMed\|15023339}}
−	** [[Spo0F]]-[[KinA]]
−
−	* '''[[Localization]]:'''
−	** cytoplasm
−
−	~~=== Database entries ===~~
−	* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU13990&redirect=T BSU13990]
−
−	* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2VLG 2VLG] (PAS domain)
−
−	* '''UniProt:''' [http://www.uniprot.org/uniprot/P16497 P16497]
−
−	* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU13990]
−
−	* '''E.C. number:'''
−
−	~~=== Additional information===~~
−
−	~~=Expression and regulation=~~
−
−	* '''Operon:''' ''[[kinA]]'' {{PubMed\|1569009}}
−
−	* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=kinA_1470026_1471846_1 kinA] {{PubMed\|22383849}}
−
−	* '''[[Sigma factor]]:''' [[SigH]] {{PubMed\|1569009}}
−
−	* '''Regulation:'''
−	** expressed under conditions that trigger sporulation ([[Spo0A]]) {{PubMed\|9644251}}
−	** induced upon addition of decoyinine (positive [[stringent response]]) {{PubMed\|23378509}}
−
−	* '''Regulatory mechanism:'''
−	** [[Spo0A]]: transcription activation {{PubMed\|9644251}}
−
−	* '''Additional information:'''
−
−	~~=Biological materials =~~
−
−	* '''Mutant:'''
−
−	* '''Expression vector:'''
−
−	* '''lacZ fusion:'''
−
−	* '''GFP fusion:'''
−
−	* '''two-hybrid system:'''
−
−	* '''Antibody:'''
−
−	~~=Labs working on this gene/protein=~~
−
−	~~=Your additional remarks=~~
−
−	~~=References=~~
−	~~==Reviews==~~
−	~~<pubmed>22303284 </pubmed>~~
−	~~==Original Publications==~~
−	<pubmed>23169620 20511506 19561131, 20413551 1846779,11292798,16166384, 11734624,9299348,12067336,18174125, 10094672, 11069677,15023339,2509430, 17350039 ,9334321,9477965,9644251, 1569009 20081035 21097618 21926229 22303282 22670053 23335417 23378509 23504013 23599347 25598361 26055117</pubmed>
−
−	~~[[Category:Protein-coding genes]]~~

@@ Line 163: / Line 163: @@
 <pubmed>22303284 </pubmed>
 ==Original Publications==
-<pubmed>23169620 20511506  19561131, 20413551 1846779,11292798,16166384, 11734624,9299348,12067336,18174125, 10094672, 11069677,15023339,2509430, 17350039 ,9334321,9477965,9644251, 1569009 20081035 21097618 21926229 22303282 22670053 23335417 23378509 23504013 23599347 25598361</pubmed>
+<pubmed>23169620 20511506  19561131, 20413551 1846779,11292798,16166384, 11734624,9299348,12067336,18174125, 10094672, 11069677,15023339,2509430, 17350039 ,9334321,9477965,9644251, 1569009 20081035 21097618 21926229 22303282 22670053 23335417 23378509 23504013 23599347 25598361 26055117</pubmed>
 [[Category:Protein-coding genes]]

@@ Line 163: / Line 163: @@
 <pubmed>22303284 </pubmed>
 ==Original Publications==
-<pubmed>23169620 20511506  19561131, 20413551 1846779,11292798,16166384, 11734624,9299348,12067336,18174125, 10094672, 11069677,15023339,2509430, 17350039 ,9334321,9477965,9644251, 1569009 20081035 21097618 21926229 22303282 22670053 23335417 23378509 23504013 23599347 </pubmed>
+<pubmed>23169620 20511506  19561131, 20413551 1846779,11292798,16166384, 11734624,9299348,12067336,18174125, 10094672, 11069677,15023339,2509430, 17350039 ,9334321,9477965,9644251, 1569009 20081035 21097618 21926229 22303282 22670053 23335417 23378509 23504013 23599347 25598361</pubmed>
 [[Category:Protein-coding genes]]

@@ Line 89: / Line 89: @@
 * '''Domains:'''
-** three tandem PAS domains in the N-terminal region of KinA, the second PAS domain is the major N-terminal determinant of KinA dimerization {{PubMed|23504013}}
+** three tandem [[PAS domain]]s in the N-terminal region of KinA, the [[second PAS]] domain is the major N-terminal determinant of KinA dimerization {{PubMed|23504013}}
-** the first PAS domain is required for NAD(+) binding {{PubMed|23599347}}
+** the first [[PAS domain]] is required for NAD(+) binding {{PubMed|23599347}}
 ** C-terminal histidine phosphotransferase domain

@@ Line 61: / Line 61: @@
 === Database entries ===
 * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/kinA.html]
@@ Line 111: / Line 112: @@
 === Database entries ===
 * '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2VLG 2VLG] (PAS domain)

@@ Line 18: / Line 18: @@
 |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=KinA KinA]
 |-
-|colspan="2" style="background:#FAF8CC;" align="center"| '''Function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/phosphorelay.html Phosphorelay]'''
+|colspan="2" style="background:#FAF8CC;" align="center"| '''Function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=kinA kinA]'''
 |-
 |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 68 kDa, 5.491

@@ Line 16: / Line 16: @@
 |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU13990 kinA]
 |-
-|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/KinA KinA]
+|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=KinA KinA]
 |-
 |colspan="2" style="background:#FAF8CC;" align="center"| '''Function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/phosphorelay.html Phosphorelay]'''

@@ Line 31: / Line 31: @@
   <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
 |-
-|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=kinA_1470026_1471846_1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:kinA_expression.png|500px]]
+|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=kinA_1470026_1471846_1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:kinA_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU13990]]
 |-
 |}

@@ Line 26: / Line 26: @@
 |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[pbpH]]'', ''[[patA]]''
 |-
-|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU13990 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU13990 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU13990 Advanced_DNA]
+|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU13990 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU13990 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU13990 DNA_with_flanks]
 |-
 |colspan="2" | '''Genetic context''' <br/> [[Image:kinA_context.gif]]