View source for Response regulator aspartate phosphatases

These proteins contain the so-called tetratricopeptide repeats (TPRs) protein-protein interaction module. They control the [[phosphorelay]] for sporulation initiation by dephosphorylating [[Spo0F]]-P or they inhibit transcription factors by protein-protein interaction (without affecting phosphorylation).
The activity of these proteins can be controlled by small peptides that are expressed as precursors, exported, and re-imported into the cell.

==The RAP proteins of ''B. subtilis'', their cognate peptides and target proteins==
* [[RapA]], [[PhrA]]: [[RapA]] dephosphorylates [[Spo0F]]-P
* [[RapB]]: dephosphorylates [[Spo0F]]-P
* [[RapC]], [[PhrC]]: [[RapC]] inhibits the DNA-binding activity of [[ComA]]-P
* [[RapD]]: [[RapD]] inhibits the DNA-binding activity of [[ComA]]-P
* [[RapE]], [[PhrE]]: [[RapE]] dephosphorylates [[Spo0F]]-P
* [[RapF]], [[PhrF]]: [[RapF]] inhibits the DNA-binding activity of [[ComA]]-P
* [[RapG]], [[PhrG]]: [[RapG]] inhibits the DNA-binding activity of [[DegU]]-P
* [[RapH]]: bifuntional protein: dephosphorylates [[Spo0F]]-P and inhibits the DNA-binding activity of [[ComA]]-P
* [[RapI]], [[PhrI]]: [[RapI]] inhibits the DNA-binding activity of [[ImmR]]
* [[RapJ]]: unknown function
* [[RapK]], [[PhrK]]: [[RapK]] inhibits the DNA-binding activity of [[ComA]]-P

==Related lists==
* [[two-component systems]]
* [[phosphorelay]]

==Reviews==
<pubmed>8730857 11587783 </pubmed>