HisD

• Description: histidinol dehydrogenase
  
  

Gene name	hisD
Synonyms
Essential	no
Product	histidinol dehydrogenase
Function	biosynthesis of histidine
Gene expression levels in SubtiExpress: hisD
Metabolic function and regulation of this protein in SubtiPathways: His
MW, pI	46 kDa, 4.777
Gene length, protein length	1281 bp, 427 aa
Immediate neighbours	hisB, hisG
Sequences	Protein DNA Advanced_DNA
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis/ acquisition of amino acids

The gene

Basic information

• Locus tag: BSU34910

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: L-histidinol + 2 NAD⁺ = L-histidine + 2 NADH (according to Swiss-Prot)

• Protein family: histidinol dehydrogenase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 1KAH (with product and NAD from Escherichia coli, 39% identity, 58% similarity) PubMed

• UniProt: O34651

• KEGG entry: [2]

• E.C. number: 1.1.1.23

Expression and regulation

• Operon: hisZ-hisG-hisD-hisB-hisH-hisA-hisF-hisI PubMed

• Expression browser: hisD PubMed

• Sigma factor:

• Regulation: repressed by casamino acids PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Ulrike Mäder, Georg Homuth, Christian Scharf, Knut Büttner, Rüdiger Bode, Michael Hecker
Transcriptome and proteome analysis of Bacillus subtilis gene expression modulated by amino acid availability.
J Bacteriol: 2002, 184(15);4288-95
[PubMed:12107147] [WorldCat.org] [DOI] (P p)